| Varieties: | General Disease Prevention Medicine |
|---|---|
| Component: | Chemical Synthetic Drugs |
| Type: | The First Class |
| Pharmacodynamic Influential Factors: | Combined Medication |
| Storage Method: | Moisture Proof |
| Veterinary Reg. No.: | 160227415 |
| Samples: |
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| Customization: |
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Generic name: Albendazole and Ivermectin Powder
Main Composition:
Per g contains:
| Albendazole | 100mg |
| Ivermectin | 2mg |
Indication:
It can be used to exorcise or kill swine nematodes, worms, tapeworms, mites and other extracorporeal parasites
Precaution:
Ivermectin is highly toxic to fish and shrimp, and the residue, package and animal waste should not contaminate the water source.
Dosage and administration:
By oral administration:
Swine: 0.7-1g of product for 10kg b.w.
Withdrawal period: 28day.
Storage: Store in a dry place, sealed and protect from light.
Shelf-life: 2 years.
| Pharmacological action |
| 1. Ivermectin is a broad-spectrum, highly potent, and low toxic macrolide antibiotic anthelmintic that primarily acts by interfering with the body γ- Aminobutyric acid, which blocks interneuron to motor neuron transmission to cause somite death, and to arthropods is to block neuromuscular transmission while leaving the soma paralyzed or dead. Therefore, ivermectin has a good repellent effect on nematodes and parasitic arthropods, and this product also reduces tick oviposition, makes the morphology of nematode eggs in body of ruminants abnormal, and makes the filamentous nematode sterile, and phase change plays the role of insecticidal eggs. |
| 2. Albendazole is a broad-spectrum, highly effective, and low toxic anthelmintic drug, and is the most widely used drug of the phenprocoumon type in veterinary clinical practice in China. Tubulin is a cellular tubulin inhibitor and also an inhibitor of energy metabolism, i.e., this product can bind to tubulin, a structural protein essential for the uptake of nutrients by parasite cells, especially to dimeric tubulin, thus hampering the polymerization of tubulin during microtubule configuration and thus killing the parasite. The product is highly effective against a wide range of nematodes and is also highly repellent against some trematode and tapeworm species |
| Combination effects |
| 1. Broadening the range of deworming: it is highly effective in combination against nematodes, trematodes, tapeworms, arthropods and almost 99% of the parasites are included. |
| 2. Repellent against ectoparasites in vivo: in combination, repellent against ectoparasites in vivo, especially against mites, ticks, skin flies in vitro, eliminates the trouble of external repellents. |
| 3. Repellent against adult worms and bug eggs: used in combination, can not light drive adult worms in vivo and in vitro, can also directly or in phase kill the bug eggs, to achieve the complete effect of deworming. |
| Common anthelmintic drugs in the clinic |
| The ideal anthelmintic must be on the basis of high efficacy, low toxicity, broad spectrum, low dosage, palatability, convenience of use, low price and residue. Currently, the anthelmintics commonly used in clinic mainly have the following. |
| Macrocyclic Intralipid anthelmintics |
| The main formulations are ivermectin, avermectin injection and its premix, but also acaricidins. The most widely used is ivermectin, which is a highly effective, broad-spectrum anthelmintic agent for intestinal nematodes and also for scabies mites. Ivermectin was given subcutaneously as a local irritant with an injection dose of 0.3 mg per kilogram of body weight. Ivermectin premix was used for feeding under stirring, and 330 g was generally added per ton of feed for 7 days. |
| Imidazothiazole anthelmintics |
| Levamisole and thiazoles are the main preparations. Levamisole is generally used with better results, there are various dosage forms such as tablets, needles and transdermal agents, which can be administered through internal services, injections and skin smears, mainly to treat porcine Ascaris lumbricoides and oesophageal oral nematodes. The dose was 7.5 mg per kilogram of body weight, administered intravenously or subcutaneously. |
| Benzimidazole anthelmintics |
| The main formulations are albendazole, nitupramine, thiabendazole, mebendazole, flubendazole, etc., of which albendazole (also known as propylthiazole) is the most widely used clinically broad-spectrum, highly effective, and low toxic insect repellent that primarily kills digestive nematodes |
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